The first section provides an introduction and historical perspective of the mucosal immune. Handbook of tuberculosis, 3volume set, edited by stefan h. Store search search title, isbn and author handbook of tuberculosis by stefan he kaufmann estimated delivery 312 business days format hardcover condition brand new this first volume of the new and most comprehensive series on tuberculosis focuses on the molecular biology of tb, thereby providing the perfect basis for forthcoming volumes on immunology and cell biology of the infection as well. As anyone who has attended tuberculosis research meeting in recent years can attest, disputes about validity of experimental animal models of tuberculosis tb erupt frequently, but mostly deteriorate into eloquence matches failing to produce satisfactory conclusions. The tb granuloma is a primary contributor to the biological heterogeneity of tb. This report was revised and renamed handbook on tb laboratory.
The second volume covers cell biology, immunology and vaccine development, while the. Volume one is coedited with eric rubin, professor of immunology and infectious diseases at the harvard school of public health, usa, and covers molecular biology and biochemistry of tuberculosis. Front matter determinants of phagocytosis, phagosome biogenesis and autophagy for mycobacterium tuberculosis \ larry s schlesinger, abul k azad, jordi b torrelles, esteban roberts, isabelle. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical.
Current figures from the world health organisation estimate 8. Of these latent individuals, only 510% will develop active tuberculosis disease in their lifetime. Tuberculosis tb is a highly complex and variable disease that presents along a spectrum of infection outcomes. Handbook of dendritic cells biology, diseases, and therapies. The granuloma acts as a site of immune cell priming. This first of the threevolume tuberculosis book series provides a comprehensive overview of molecular biological and biochemical aspects of tuberculosis. The failure of immunemediated clearance is due to multiple strategies adopted by m. As with the other volumes in this series, this will become a reference for anyone interested in the immunology and cell biology of m.
Autophagy in immunity against mycobacterium tuberculosis. Handbook of tuberculosis is a very useful tool for clinicians who care for patients with tuberculosis. Nk cells positively modulate adaptive immune responses against mycobacteria, and thus contribute to the mechanisms that ultimately lead to control of m. This second of the threevolume tuberculosis book series provides a comprehensive overview of immunological and cell biological aspects of tuberculosis. Despite promulgation of multipronged strategies to prevent and control tb, there is no significant downfall occurring in the number of new cases, and adding to this is the relapse of the disease due to the emergence of antibiotic resistance and the. It forms the preeminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Handbook of tuberculosis stefan h e kaufmann, warwick j. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of tb. Mycobacterium tuberculosis interactions with dendritic. The role of autophagy as a cellautonomous antimicrobial defense has been suspected for a long. It presents the preeminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. The main purpose of the series is to summarize the existing knowledge on tuberculosis and, as expected, this book.
In its large 812x 11format, handbook of mucosal immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. It is also useful to researchers due to the comprehensive information provided on immunology, cell biology, molecular biology, and biochemistry. Kaufmann, 9783527318889, available at book depository with. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e. Diane m cappelletty, pharmd college of pharmacy, the university of toledo, toledo, oh audience. The resurgence of tuberculosis worldwide has intensified research efforts directed at examining the host defense and pathogenic mechanisms operative in mycobacterium tuberculosis infection. Immunology and cell biology presents the preeminent resource for all aspects of cell biology and immunology of tuberculosis, including.
Handbook of tuberculosis molecular biology and biochemistry edited by stefan h. The set of three volumes of the handbook of tuberculosis, which is aimed at a broad readership, cover different specialty areas. Handbook of tuberculosis is a wellrounded book written by renowned researchers at the johns hopkins center for tuberculosis research. Infection with mycobacterium tuberculosis causes a variety of clinical conditions ranging from lifelong asymptomatic infection to. Tuberculosis tb caused by the intracellular pathogen, mycobacterium tuberculosis mtb, claims more than 1. Handbook on tuberculosis laboratory diagnostic methods in. Handbook of tuberculosis, 3 volume set microbiology.
There are 9 million cases of active tuberculosis reported annually. However, it may become active due to malnutrition or another disease, in which case they will show symptoms and become contagious. This chapter on pathology and pathogenesis of bacterial infections summarizes the different types and mechanisms of pathology caused by bacteria once they cross mucosal or cutaneous barriers, and either multiply in extracellular spaces or take up residence within host cells. Characterization of lung inflammation and its impact on. Determinants of phagocytosis, phagosome biogenesis. Mycobacterium tuberculosis encounters three main types of professional antigen.
View table of contents for handbook of tuberculosis. Tuberculosis tb in humans is caused by infection with mycobacterium tuberculosis, which is a nonmotile, slowgrowing, rodshaped bacillus. It provides the basis for the threevolume set by focusing on the genomic and genetic nature of the pathogen as well as current medical advancements that combat the bacterium on a molecular level. The handbook of tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study each volume provides an essential resource to molecular and cell biologists, bacteriologists. This report was revised and renamed handbook on tb laboratory diagnostic. Arslan library is the ultimate source to download free medical books in pdf. In this lecture, the molecular mechanisms in tuberculosis have been discussed where we can see the following topics getting covered. Immunology and cell biology presents the preeminent resource for all. Immunology and cell biology presents the preeminent resource for all aspects of cell biology and immunology of tuberculosis. Molecular biology and biochemistry highlights the molecular mechanisms of tuberculosis. Handbook of tuberculosis the lancet infectious diseases.
Phagocytosis of tubercle bacilli by antigenpresenting cells in human lung alveoli initiates a complex infection process by mycobacterium tuberculosis and a potentially protective immune response by the host. Warwick britton, professor of medicine at the university of sydney and head of the mycobacterial research program at the centenary institute, sydney, australia. Handbook of tuberculosis 3volume set edited by stefan h. This chapter discusses distinctive features of dcs and macrophages relevant to three processes that are decisive to the initiation and establishment of pulmonary immunity. Kaufmann is founding director of the max planck institute for infection biology, berlin. Volume three is coedited with paul van helden, professor of medical biochemistry at stellenbosch university, south africa, and covers clinics, diagnostics, therapy, and epidemiology. Systemic inflammation that occurs with increasing age inflammaging is thought to contribute to the increased susceptibility of the elderly to several disease states. Handbook of tuberculosis stefan h e kaufmann, paul van. Coinciding with the first tb therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the. Handbook of tuberculosis wiley online books wiley online library. This second volume in the handbook of tuberculosis series covers the immunology and cell biology of mycobacterium tuberculosis, the etiologic agent of tuberculosis. Carlos e figueroa castro, md medical college of wisconsin description. Molecular biology is now becoming more important in the diagnosis of mycobacteria. Several advances in clinical management, molecular biology, biochemistry, immunology, and cell biology have.